Identifying Impact of Donor/Recipient Sex Match in Cord Blood Transplant

In this retrospective study of 191 adults who underwent single cord blood transplantation (CBT), researchers found that donor/recipient sex compatibility did not have a significant impact on survival. A multivariate analysis using female donor/female recipient transplants as the reference revealed that female/male transplants had a higher incidence of extensive chronic GVHD (hazard ratio (HR): 2.97, p=0.02) and male/female transplants had a lower incidence of platelet engraftment (HR: 0.56, p=0.02). Despite these differences, there was no increase in mortality following sex-mismatched CBT.

Konuma T, et al. Bone Marrow Transplant