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Recent Research

Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.

  • Novel cytogenetic-based risk scores predict HCT outcomes for patients with CLL

    September 2019

    Kim HT, et al., Clin Cancer Res – Researchers have developed a prognostic model for patients with chronic lymphocytic leukemia (CLL) on the probable outcomes of undergoing reduced-intensity hema-topoietic cell transplantation (HCT).

    The model incorporates disease status, comorbidity index, lymphocyte count, and white blood cell count at HCT, plus cytogenetic assessments of del(17p) and karotypic abnormalities to stratify patients into four risk groups. 

     

    Read More

  • New Prognostic System for Patients with Relapsed Follicular Lymphoma

    May 2018
    Sureda A, et al. Cancer – A large-scale, long-term study of patients with relapsed follicular lymphoma (FL) has identified a new prognostic scoring system to assess risks of allogeneic hematopoietic cell transplantation (HCT). Results have shown that HCT can lead to a 5-year overall survival (OS) of 61% and a progression-free survival of 52%.

    Read More

  • Experts Debate Allo-HCT for Patients with Hodgkin Lymphoma Relapsing After Auto-HCT

    May 2018
    Peggs KS and Moscowitz CH. Blood Advances – In a Point-Counterpoint feature in Blood Advances, two prominent hematologists, Drs. Karl S. Peggs and Craig H. Moscowitz, debate “Should all patients with Hodgkin lymphoma who relapse after autologous HCT be considered for allogeneic HCT?”

    Read More

  • Study Compares 5-Year Outcomes of Auto- vs. Allo-HCT in Patients with High-Risk FL

    May 2018
    Smith SM, et al. Cancer – Patients with high-risk follicular lymphoma (FL), defined as relapse or progression within 2 years of frontline chemoimmunotherapy, can achieve a 5-year OS of 70% after autologous HCT.

    Read More

  • Study Shows Age Doesn't Affect Survival in HCT for NHL

    April 2018
    Shah NN, et al. Blood Advances – Results from a study of 1,629 older adults show that older age per se should not make a patient ineligible for an allogeneic hematopoietic cell transplant (HCT) in non-Hodgkin lymphoma (NHL).

    Read More

  • Auto-HCT Improves Survival in Patients with FL and Early Therapy Failure

    February 2018
    Casulo C, et al. Biol Blood Marrow Transplant – Patients with follicular lymphoma (FL) experiencing therapy failure within 2 years of frontline chemotherapy had better outcomes with an autologous HCT (auto-HCT) compared to a matched cohort of patients who did not undergo auto-HCT.

    Read More

  • Long-Term Outcomes Show Effectiveness of Reduced-Intensity HCT in MCL

    February 2018
    Robinson SP, et al. Bone Marrow Transplant – Patients with mantle cell lymphoma (MCL) who have relapsed after an autologous transplant generally have a poor prognosis. Further treatment options include a second autologous transplant, an allogeneic transplant, or various alternative treatment strategies including novel agents.

    Read More

  • New Clinical Recommendations on the Role of HCT in Mature T Cell and NK/T Cell Lymphomas

    December 2017
    Kharfan-Dabaja MA, et al. Biol Blood Marrow Transplant – New recommendations on the role of hematopoietic cell transplantation (HCT) for mature T cell and natural killer (NK)/T cell lymphomas outline clinical practice algorithms for 14 histological subtypes.

    Read More

  • Maintenance with Rituximab Prolongs Survival after Auto-HCT for Mantle Cell Lymphoma

    November 2017
    Le Gouill S, et al. N Engl J Med – Rituximab maintenance therapy after autologous hematopoietic cell transplantation (HCT) significantly prolonged event-free survival, progression-free survival, and overall survival in patients with mantle cell lymphoma, according to a phase III randomized study of 299 patients <66 years old.

    Read More

  • Recent HCT Survival Improvements Reported for Hodgkin Lymphoma

    June 2017
     Hegerova L, et al. Bone Marrow Transplant – This study of 72 patients with relapsed/refractory Hodgkin lymphoma (HL) has shown that allogeneic HCT outcomes have improved over time, primarily due to reductions in non-relapse mortality and decreased early relapse.

    Read More

  • Five-Year Disease-Free Survival Greater Than 80% with Auto-HCT for Hodgkin and DLBC Lymphoma

    April 2017
    Myers R, et al. Biol Blood Marrow Transplant –In this multi-center study of 1,617 patients who survived for at least two years following autologous hematopoietic cell transplantation (auto-HCT) for Hodgkin lymphoma (HL) or diffuse large B-cell lymphoma (DLBCL), 5-year disease-free survival (DFS) was >80%.

    Read More

  • Early Auto-HCT Improves Survival in High-Risk FL Patients

    April 2017
    Casulo C, et al. Biol Blood Marrow Transplant – Patients with follicular lymphoma (FL) experiencing therapy failure within 2 years of frontline rituximab-based therapy have better outcomes when they undergo autologous hematopoietic cell transplantation (HCT) early (≤1 year from therapy failure), according to research results presented at the BMT Tandem Meetings.

    Read More

  • Report: Long-Term Follow Up Needed after HCT for CLL

    January 2017
    van Gelder M, et al. Bone Marrow Transplant – Although allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for patients with chronic lymphocytic leukemia (CLL), a new study shows that HCT results in a higher mortality rate in transplant recipients compared to an age-, sex- and calendar year-matched general population.

    Read More

  • ASBMT Report: The Role of Allogeneic Transplant for CLL

    November 2016
    Kharfan-Dabaja MA, et al. Biol Blood Marrow Transplant – Although allogeneic hematopoietic cell transplantation (HCT) is currently relegated to later stages of relapsed or refractory chronic lymphocytic leukemia (CLL), novel targeted therapies have altered clinical decision-making for the disease.

    Read More

  • MRD Accurately Predicts Survival in Patients with CLL

    October 2016
    Kovacs G, et al. J Clin Oncol – Minimal residual disease (MRD) quantification results in improved progression-free survival (PFS) prediction in patients who achieve partial response (PR) and those who achieve complete remission (CR) after completion of chemotherapy or immunotherapy to treat chronic lymphocytic leukemia (CLL), according to combined results from two phase III studies.

    Read More

  • Haploidentical and Matched Related Donor HCT Result in Comparable Outcomes

    June 2016
    Ghosh N, et al. J Clin Oncol – In this multi-center study of 987 adults with lymphoma undergoing HCT with post-transplant cyclophosphamide, outcomes were comparable between haploidentical (n=180) and matched sibling donors (MSD; n=807).

    Read More

  • HCT Yields Over 80% 3-Year Survival and Low Relapse in High-Risk FL Patients

    May 2016
    Laport GG, et al. Biol Blood Marrow Transplant – Hematopoietic cell transplantation (HCT) using reduced-intensity conditioning with rituximab yields excellent survival in high-risk patients with follicular lymphoma (FL), according to results of a prospective phase II study by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).

    Read More

  • Review: Advances in Allo-HCT Expand Use in Older Patients with NHL

    May 2016
    Fenske TS, et al. Biol Blood Marrow Transplant – In this review, the authors present data supporting allogeneic HCT as a therapeutic option for patients with non-Hodgkin lymphoma (NHL) diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma focusing on patients over age 60.

    Read More

  • Prognostic Model Predicts HCT Outcomes in Patients with DLBCL

    April 2016
    Fenske TS, et al. Br J Haematol – Researchers have developed a prognostic model to identify which patients with diffuse large B-cell lymphoma (DLBCL) who have failed a prior autologous transplant would best benefit from a subsequent allogeneic transplant.

    Read More

  • Haploidentical, Unrelated Donor HCT Outcomes Comparable in Lymphoma

    March 2016
    Kanate AS, et al. Blood – Reduced-intensity HCT using haploidentical or matched unrelated donors (URD) yields comparable outcomes, according to a study of 917 adults transplanted for lymphoma.

    Read More

  • Allo- Better than Auto-HCT for Early Relapsed or Refractory Follicular Lymphoma

    March 2016
    Lunning MA, et al. Brit J Haematol – An analysis of 44 patients with early relapsed or refractory follicular lymphoma (FL) shows a significant difference in 3-year event-free survival (EFS) between allogeneic and autologous transplantation (80% vs. 42%, respectively; p<0.015), but only in patients with previous remission duration of ≤12 months.

    Read More

  • Meta-Analysis: Outcomes of HCT in Hodgkin Lymphoma Have Improved Over Time

    February 2016
    Rashidi A, et al. Bone Marrow Transplant – This meta-analysis encompassing 1,850 patients with Hodgkin lymphoma (HL) has found that hematopoietic cell transplantation (HCT) outcomes in HL have improved since 2000.

    Read More

  • HCT for Relapsed or Refractory Follicular Lymphoma Leads to 5-Year Survival of 52%

    December 2015
    Sureda A, et al. ASH abstract oral presentation, December 2015 – Patients with relapsed/refractory follicular lymphoma (FL) can experience a 5-year progression-free survival (PFS) of 52%, according to the results of the largest FL study to date of 1,538 allogeneic hematopoietic cell transplant (HCT) recipients whose outcomes were reported to two major transplant registry databases.

    Read More

  • Comparable Outcomes in Unrelated Donor vs. Haploidentical HCT with Cyclophosphamide

    December 2015
    Mussetti A, et al. ASH abstract oral presentation, December 2015 – Lower-intensity hematopoietic cell transplantation (HCT) using haploidentical donors and post-transplant cyclophosphamide for GVHD prophylaxis can achieve outcomes comparable to HLA-matched unrelated donor transplants, according to results of a retrospective study of 917 adults with Hodgkin or Non-Hodgkin lymphoma.

    Read More

  • Prognostic Model Identifies Relapsed DLBCL Patients Who Can Achieve Durable Progression-Free Survival After Allogeneic HCT

    December 2015
    Fenske TS, et al. ASH abstract oral presentation, December 2015 – A new prognostic model identifies a subgroup of adults with diffuse large B-cell lymphoma (DLBCL) relapsing after an autologous transplant who can experience long-term progression-free survival following an allogeneic transplant.

    Read More

  • Survival 80% or Higher with Allogeneic HCT after Failed Autologous HCT for Lymphoma

    December 2015
    Rezvani AR, et al. Bone Marrow Transplant – In a study of 47 patients with lymphoma who had failed prior autologous hematopoietic cell transplantation (HCT), 3-year overall survival was 81% after allogeneic HCT with a conditioning regimen using total lymphoid irradiation and antithymocyte globulin (TLI-ATG).

    Read More

  • Survival 65% or Higher in HCT for Progressive or Refractory Follicular Lymphoma

    December 2015
    Yano S, et al. Bone Marrow Transplant – A multi-center retrospective study of reduced-intensity hematopoietic cell transplantation (HCT) in 46 adults with follicular lymphoma has shown that this therapy can result in a 5-year overall survival (OS) of 71.6%.

    Read More

  • Allogeneic HCT Better than Autologous HCT for Progression-Free Survival in Follicular Lymphoma

    September 2015
    Klyuchnikov E, et al. Biol Blood Marrow Transplant – In adults with follicular lymphoma (FL), reduced-intensity allogeneic hematopoietic cell transplantation (HCT) yields better long-term survival compared to autologous HCT, according to results of a study of 518 rituximab-treated patients with FL transplanted between 2000 and 2012.

    Read More

  • Excellent Outcomes in Outpatient Autologous HCT for Patients with Myeloma or Lymphoma

    July 2015
    Graff TM, et al. Bone Marrow Transplant – Researchers comparing outcomes of 230 patients with myeloma or lymphoma who underwent autologous hematopoietic cell transplantation (HCT) on an inpatient vs. outpatient basis within a single transplant program have found comparable outcomes in the two cohorts.

    Read More

  • No Clinical Benefit in Adding Radioimmunotherapy to BEAM Conditioning in Autologous HCT for Relapsed DLBCL

    March 2013
    Vose JM, et al. J Clin Oncol — In patients with relapsed diffuse large B-cell lymphoma (DLBCL) undergoing autologous hematopoietic cell transplantation (HCT), adding radioimmunotherapy to the standard BEAM conditioning regimen provides no clinical benefit, according to results from a randomized phase III clinical trial conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).

    Read More

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Choose a Topic

  • All Topics
  • ASH 2017
  • AML
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  • ASH 2018
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