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Recent Research

Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.

  • Geriatric impairments in cancer patients affect caregiver health, QOL

    May 2019

    Kehoe LA, et al., J Am Geriatr Soc – A study of 541 patients age 70 and older with advanced cancer has shown a significant association between the number of patient geriatric assessment (GA) impairments and poorer emotional health and quality of life (QOL) in caregivers. The researchers conclude that clinicians should address caregiver needs when patients have a high number of GA impairments.

    Read More

  • Low-grade aGVHD positively affects OS for patients with early disease stage ALL

    April 2019

    Yeshurun M, et al., Blood Advances – Development of low-grade acute graft-versus-host disease (aGVHD) lowers relapse risk and positively affects overall survival (OS) for patients with acute lymphoblastic leukemia (ALL) in complete remission one and two). That’s the conclusion of researchers who aimed to better understand the graft-versus-leukemia effect in patients with ALL, and how disease stage and severity of GVHD impacts hematopoietic cell transplant outcomes.

    Read More

  • Geriatric assessment and targeted interventions recommended for older patients undergoing allogeneic HCT

    February 2019

    With an increasing number of older patients undergoing allogeneic hematopoietic cell transplantation (HCT), researchers studied the incidence and impact of transplant-related geriatric syndromes. The results suggest that older patients may benefit from geriatric assessment and targeted interventions aimed at i

    Read More

  • Event-free survival improved with midostaurin for patients with FLT3-ITD-mutated AML

    February 2019

    The addition of the multi-targeted kinase inhibitor, midostaurin, to chemotherapy followed by allogeneic hematopoietic cell transplantation (HCT) significantly improved event-free survival (EFS) for patients with acute myeloid leukemia (AML) with FLT 3 internal tandem duplication (ITD). That’s according to the

    Read More

  • Timing of molecular testing may enhance treatment decisions for patients with AML

    January 2019

    For patients with acute myeloid leukemia (AML), the timing of molecular testing can enhance patient management decisions and clinical trials recommendations. Researchers highlighted evidence that supports molecular testing at diagnosis, complete remission and relapse. At diagnosis, gene panel sequencing

    Read More

  • Geriatric assessment helps inform decision making and management for older adults with AML

    November 2018

    Loh KP and Klepin HD. Blood Advances - The presenters of this Blood Advances Talk recommend geriatric assessment for older adults with acute myeloid leukemia (AML). They reason that adults of the same age can vary based on underlying health status and physiologic reserve, therefore, decision making and management cannot be optimized using strategies based on chronologic age.

    Read More

  • Emerging prognostic factors identify older adults with high-risk AML likely to benefit from HCT

    November 2018

    Veltri L, et al. Bio Blood Marrow Transplant - In a recent study, researchers analyzed hematopoietic cell transplant (HCT) outcomes in 185 patients (age >65) with high-risk acute myeloid leukemia (AML) and found the strongest independent risk factor for overall survival (OS) and relapse was associated with achievement of measurable residual disease negative status prior to HCT. Additional prognostic factors identified in this study could help identify patients most likely to benefit from HCT treatment.  

    Read More

  • How I Treat Older Adults with Sickle Cell Disease

    October 2018

    Thein SL and Howard J., Blood Journal – In this installment of the “How I treat…” series, the authors highlight that for patients with sickle cell disease, survival has significantly improved. Consequently, adults face new long-term risks of their disease as well as age-related conditions.

     

    Read More

  • Using quality of life to inform treatment decisions for older patients with cancer

    September 2018

    A Task Force of the International Society of Geriatric Oncology recommends all health care professionals involved in the care of older patients with cancer should place a greater focus on quality of life (QOL), and treatment decisions should not be made based on chronological age alone. (Scotté F, et al. Annals of Oncology)

    Discover additional QOL recommendations and guidance from the task force

    Read More

  • Risk-Adapted Treatment Strategies for Older Patients with AML

    July 2018
    Arellano M, et al. Cancer – In this review, the authors argue that the current treatment algorithm for older patients with acute myeloid leukemia (AML) ─ induction, followed by consolidation (with or without transplantation) versus hospice ─ is no longer sufficient.

    Read More

  • Allogeneic HCT is Feasible for Patients Aged ≥70 Years

    June 2018
    Al Malki MM, et al. Biol Blood Marrow Transplant – Patients aged 70 years and older undergoing reduced-intensity allogeneic HCT can achieve 2-year overall survival rates of 68%.

    Read More

  • Frailty Assessments Can Inform Treatment Decisions in Patients with Hematologic Malignancies

    March 2018
    Abel GA, et al. Blood – In this review, the authors outline how hematologists can make better treatment recommendations for their patients by incorporating several easy-to-use frailty assessment tools into their practice.

    Read More

  • Study Shows Age Doesn't Affect Survival Outcomes in Patients with Non-Hodgkin Lymphoma Who Undergo Allogeneic HCT

    February 2018

    Results from a retrospective study presented at the 2018 BMT Tandem Meetings dispute age as a limiting factor to transplant eligibility, showing no differences in 4-year outcomes for patients older or younger than age 65.

    Read More

  • Measuring Frailty Can Improve Existing Prognostic Tools

    December 2017
    Hegde A, et al. Bone Marrow Transplant – Because frailty is prevalent in many patients pre- and post-transplant and is associated with age-independent adverse transplant outcomes, the authors of this review recommend incorporating a frailty assessment to optimize the predictive ability of existing pre-transplant assessment (PTA) tools across all age groups and particularly in elderly individuals.

    Read More

  • Disease Risk Index is Important Prognostic Factor for Older HCT Patients

    September 2017
    He F, et al. Biol Blood Marrow Transplant – A study of 196 patients age 60-75 years with hematologic malignancies undergoing reduced-intensity conditioning (RIC) hematopoietic cell transplantation (HCT) has found that the Disease Risk Index (DRI) score is a significant prognostic factor for post-transplant relapse, treatment failure and mortality.

    Read More

  • Older Patients with MDS: Uncovering Barriers to Allogeneic HCT

    August 2017
    Getta BM, et al. Biol Blood Marrow Transplant – Only one-third of all patients with myelodysplastic syndromes (MDS) referred to an academic center undergo hematopoietic cell transplantation (HCT), according to a study of 362 patients with MDS treated at Memorial Sloan Kettering Cancer Center.

    Read More

  • Improved Outcomes and Increased Use of HCT in Patients ≥70 Years

    August 2017
    Muffly L, et al. Blood – Overall and progression-free survival after allogeneic hematopoietic cell transplantation (HCT) in patients ≥70 years with hematologic malignancies increased significantly between 2000 and 2013, according to a multi-center study.

    Read More

  • Patients with MDS Responding to HMAs Have Better HCT Outcomes

    July 2017
    Festuccia M, et al. Biol Blood Marrow Transplant – Patients with myelodysplastic syndromes (MDS) who undergo hematopoietic cell transplantation (HCT) while still responding to hypomethylating agents (HMAs) have lower rates of post-HCT relapse, according to a study of 125 patients with MDS.

    Read More

  • Comorbidity Scores are Prognostic of Overall Survival in Relapsed/Refractory AML

    July 2017
    Middeke JM, et al. Biol Blood Marrow Transplant – Comorbidity evaluations can provide clinically useful prognostic information at the time of diagnosis of relapsed or refractory acute myeloid leukemia (AML), according to results of a phase II trial.

    Read More

  • Cytogenetic Risk Prognostic of HCT Outcomes in Older Patients with AML in CR2

    May 2017
    Michelis FV, et al. Cancer – Allogeneic hematopoietic cell transplantation (HCT) is a curative treatment option for older patients with acute myeloid leukemia (AML) in second complete remission (CR2), particularly for those with favorable or intermediate cytogenetic risk, according to researchers who studied 169 transplants at 78 centers.

    Read More

  • Allogeneic HCT is Feasible for Patients ≥70 Years

    April 2017
    Sorror ML, et al. Biol Blood Marrow Transplant – New research presented at the BMT Tandem Meetings shows that patients aged 70 years and older can have comparable hematopoietic cell transplantation (HCT) outcomes to those of younger patients and that comorbidities and disease risks, not age, should be used to evaluate potential candidates.

    Read More

  • Comparable HCT Survival and Incidence of Toxicity for Patients ≥60 Years

    December 2016
    Shah GL, et al. ASH abstract oral presentation, December 2016 – Survival of patients ≥60 years undergoing ex vivo CD34+ selected reduced-intensity hematopoietic cell transplantation (HCT) was comparable to that of patients <60 years, according to research presented at ASH.

    Read More

  • Careful Selection of Older Patients with MDS Can Improve HCT Outcomes

    November 2016
    Heidenreich S, et al. Biol Blood Marrow Transplant – Researchers analyzing 313 patients over age 70 (median age 72 years) whose transplant outcomes were reported to the registry of the European Society for Blood and Marrow Transplantation (EBMT) found that careful selection of patients can significantly improve hematopoietic cell transplantation (HCT) outcomes.

    Read More

  • Review: Advances in Allo-HCT Expand Use in Older Patients with NHL

    May 2016
    Fenske TS, et al. Biol Blood Marrow Transplant – In this review, the authors present data supporting allogeneic HCT as a therapeutic option for patients with non-Hodgkin lymphoma (NHL) diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma focusing on patients over age 60.

    Read More

  • Decision-Making Recommendations for Older Adults Considering HCT

    April 2016
    Randall J, et al. Bone Marrow Transplant – This article outlines strategies to help older adults make an informed decision about transplantation, recognizing that older adults will likely have different functional and psychosocial considerations at this stage in life.

    Read More

  • Increased Use of and Improved Survival in HCT for Patients ≥70 Years

    February 2016
    Muffly L, et al. BMT Tandem Meetings abstract oral presentation, February 2016 – A study of 1,106 patients ≥70 years undergoing allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2013 has found that overall survival has improved significantly and use of HCT in this patient cohort has increased over the last decade.

    Read More

  • Review: HCT for Patients with AML in First Complete Remission

    January 2016
    Cornelissen JJ, et al. Blood – In this review, part of a Blood journal special review series on acute myeloid leukemia (AML), the authors note that although the majority of patients AML enter remission upon induction chemotherapy, the risk of relapse is considerable and it varies greatly according to age and genetic subtype.

    Read More

  • Patients Age 65 Years and Older with MDS Should Not Be Limited from Undergoing HCT

    December 2015
    Atallah E, et al. ASH abstract oral presentation, December 2015 – Patients over age 65 with myelodysplastic syndromes (MDS) should be considered transplant eligible, according to an oral presentation at the 2015 ASH Annual Meeting.

    Read More

  • Meta-Analysis: Age Not a Determining Factor in HCT Selection for AML

    November 2015
    Rashidi A, et al. Biol Blood Marrow Transplant – A meta-analysis of 749 patients >60 years undergoing hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) has shown that older age per se should not be the sole criterion against selecting HCT therapy.

    Read More

  • Low Non-Relapse Mortality, GVHD after HCT in Older Patients with AML in First Remission

    November 2015
    Devine SM, et al. J Clin Oncol – A multi-center phase II study of 114 patients aged 60-74 years with AML in first remission has found that reduced-intensity HCT can lead to a low incidence of non-relapse mortality (NRM) and graft-versus-host disease (GVHD).

    Read More

  • HCT Yields Best Outcomes in Patients ≥60 Years with AML

    October 2015
    Versluis J, et al. Lancet Haematol – A study analyzing a series of four multi-center trials has shown significantly better 5-year overall survival for allogeneic hematopoietic cell transplantation (HCT) in patients aged 60 years and older with acute myeloid leukemia (AML) when compared with no and other post-remission therapies.

    Read More

  • AML patients ≥70 Achieve 60% Estimated Survival with UCB HCT

    October 2015
    Sandhu KS, et al. Biol Blood Marrow Transplant – In this single-center retrospective study of 22 transplant recipients 70 years and older, 10 patients undergoing umbilical cord blood (UCB) transplantation had an estimated 2-year overall survival of 60%.

    Read More

  • Non-Myeloablative Haploidentical HCT in Older Patients

    September 2015
    Kasamon YL, et al. J Clin Oncol – This retrospective, single-center study found that age had no significant effect on survival of 271 patients age 50-75 years undergoing non-myeloablative haploidentical hematopoietic cell transplantation (HCT).

    Read More

  • Review: How I Treat the Older Patient with AML

    January 2015
    Ossenkopple G, et al. Blood – In this installment of the “How I treat” series in Blood, the authors discuss the highly heterogeneous clinical biology of acute myeloid leukemia (AML) among patients and how those variations are relevant for prognosis and treatment choice.

    Read More

  • Progress Report: Update of BMT CTN State of the Science Symposium

    February 2014
    Ferrara JLM. Biol Blood Marrow Transplant – In this 2014 report, the author updates the status of the 11 hematopoietic cell transplantation (HCT) clinical trials identified as having the highest scientific priority at the 2007 State of the Science Symposium convened by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).

    Read More

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Choose a Topic

  • All Topics
  • ASH 2017
  • AML
  • MDS
  • Lymphomas and CLL
  • Older Patient HCT
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  • GVHD
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  • ASH 2018
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