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Recent Research

Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.

  • Does age at time of HCT for patients with sickle cell disease impact outcomes?

    June 2019

    Cappelli B, et al. Haematologica – The youngest of three age-based patient cohorts (age 0-5 years) in a study of 736 patients with sickle cell disease (SCD) undergoing HLA-identical sibling hematopoietic cell transplantation (HCT) experienced 4-year event-free survival of 93%, results the researchers characterized as “excellent.” 

    Read More

  • Neurocognition stabilizes after HCT for patients for sickle cell disease-induced cognitive decline

    February 2019

    In addition to the risk of stroke and cognitive decline, children with sickle cell disease (SCD) may lose approximately one IQ point per year on a full scale IQ (FSIQ) test. For the first time, researchers report stabilization of IQ and central nervous system (CNS) outcomes after unrelated allogeneic hematopoie

    Read More

  • How I Treat Older Adults with Sickle Cell Disease

    October 2018

    Thein SL and Howard J., Blood Journal – In this installment of the “How I treat…” series, the authors highlight that for patients with sickle cell disease, survival has significantly improved. Consequently, adults face new long-term risks of their disease as well as age-related conditions.

     

    Read More

  • Consensus Statement on HCT Late Effects Screening Guidelines in Hemoglobinopathies

    June 2018
    Shenoy S, et al. Biol Blood Marrow Transplant – An international panel of HCT experts has updated late effects screening guidelines for pediatric transplantation for hemoglobinopathies, focusing on sickle cell disease and thalassemia.

    Read More

  • Ethical Challenges in HCT for Sickle Cell Disease

    February 2018
    Nickel RS, et al. Biol Blood Marrow Transplant – People with sickle cell disease (SCD) experience a shortened life expectancy, painful and debilitating symptoms, and a lowered quality of life. Thus, clinicians face ethical dilemmas when counseling their patients with SCD on whether to pursue HCT, which is currently the only potential cure for the disease, but which comes with a risk of mortality.

    Read More

  • Study Identifies Key Factors Influencing the Decision to Pursue HCT for Sickle Cell Disease

    January 2018
    Khemani K, et al. Biol Blood Marrow Transplant – Currently, hematopoietic stem cell transplant (HCT) is the only treatment for sickle cell disease (SCD) with a curative intent.

    Read More

  • HCT Significantly Improves Quality of Life in Children with Sickle Cell Disease

    December 2017
    Bernaudin F, et al. ASH abstract oral presentation, December 2017 – Children with sickle cell disease (SCD) have significantly better physical health and school functioning after transplantation than do those receiving chronic transfusion, according to results of a donor/no donor study of 67 patients with SCD.

    Read More

  • 90% Survival, Low GVHD at Two Years after Alternative Donor HCT for SCD

    August 2017
    Gilman AL, et al. Blood Advances – A study of patients with symptomatic sickle cell disease (SCD) who underwent CD34+ cell-selected, T-cell–depleted peripheral blood HCT from a mismatched family member or unrelated donor has resulted in a 2-year overall survival rate of 90%.

    Read More

  • Large-Scale Study Shows Greater Than 90% Survival After HCT for Sickle Cell Disease

    January 2017
    Gluckman E, et al. Blood – Researchers analyzing the outcomes of 1,000 patients with sickle cell disease (SCD) who underwent identical sibling hematopoietic cell transplantation (HCT) between 1986 and 2013 characterized the 5-year survival as “excellent” and concluded that their results “confirm this is an accepted treatment for severe SCD.”

    Read More

  • One-Year OS of 86% Achieved with Unrelated Donor HCT for Children with SCD

    October 2016
    Shenoy S, et al Blood – This multi-center phase II trial conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) analyzed outcomes of 29 children (age range 6-19 years) with sickle cell disease (SCD) who underwent reduced-intensity conditioning unrelated donor hematopoietic cell transplantation (HCT) between 2008 and 2014.

    Read More

  • Expanding Use of HCT to Treat Sickle Cell Disease

    June 2016
    Arnold SD, et al. Br J Haematol – In this review of hematopoietic cell transplantation (HCT) for sickle cell disease (SCD), the authors outline the indications for transplantation in both children and adults, and note that overall survival in matched sibling HCT exceeds 90%.

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  • Improved Quality of Life, No GVHD after HCT in Adults with Sickle Cell Disease

    March 2016
    Saraf SL, et al. Biol Blood Marrow Transplant – HCT using an innovative conditioning regimen can result in a cure with marked improvements in quality of life for patients with high-risk sickle cell disease, according to a study of 13 adults transplanted using matched related donors.

    Read More

  • Three-Year Survival of 94% in HCT for Sickle Cell Disease

    December 2015
    Cappelli B, et al. ASH abstract oral presentation, December 2015 – Results presented at ASH from a study of 1,000 matched sibling donor transplants in patients with severe sickle cell disease (SCD) have demonstrated a three-year overall survival of 94% and an event-free survival of 90%.

    Read More

  • Early HCT for SCD in Children is Preferred Therapy Prior to Onset of SCD Complications

    December 2015
    Satwani P, et al. ASH abstract oral presentation, December 2015 – Hematopoietic cell transplantation (HCT) to treat sickle cell disease (SCD) can result in up to 96% survival at two years, according to research results presented at the ASH Annual Meeting.

    Read More

  • Review: HLA-Identical Sibling HCT to Treat Sickle Cell Disease in Children

    November 2015
    Walters MC, et al. Biol Blood Marrow Transplant – In this of review of HLA-identical sibling transplantation to treat sickle cell disease (SCD) in children, the authors assess the risk of mortality and compare published rates of survival in SCD patients treated and not treated by HCT.

    Read More

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Choose a Topic

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