Comparable Survival in Cord Blood and Adult Donor HCT for ALL

A study of 802 adults transplanted for acute lymphoblastic leukemia (ALL) in first or second complete remission has found comparable outcomes using three different unrelated donor graft sources: mismatched single or double cord blood (CB; n=116), peripheral blood progenitor cells (PBPC; n=546), and bone marrow (BM; n=140). Recipients were similar except CB recipients were younger, more likely to be non-white, and to have low white blood cell count at diagnosis. Three-year survival was comparable among patients receiving CB (44%), matched (44%) and mismatched (43%) adult donor transplants (BM or PBPC).

Marks DI, et al. Haematologica