Geriatric Assessments Can Predict HCT Outcomes in Older Adults

A geriatric assessment (GA) tool has independent prognostic utility in allogeneic HCT outcomes in patients aged 50 years and older, according to a study of 203 older adults. Researchers evaluated overall function, disability, frailty, comorbidity, mental health, nutrition, and inflammation in HCT candidates ≥50 years using established and validated GA measurement tools. At a median follow up of 36 months, poor performance on four GA scales (function, disability, mental health and inflammation) were each significantly associated with inferior survival, and the prognostic effect of these GA variables was significantly greater in recipients ≥60 years.

Muffly LS, et al. Haematologica