New research into a composite prognostic index combining age and comorbidities has validated the utility of the index to guide clinical decision-making in HCT. The researchers analyzed data from 3,033 consecutive transplants at five institutions, and randomly assigned patients into: 1) a training set to develop weights for age intervals; or 2) a validation set to assess the performance of prognostic models. A composite comorbidity/age score had statistically significantly higher c-statistic estimates for prediction of non-relapse mortality and survival compared with age alone. The researchers concluded that age alone is a poor prognostic factor, but incorporating age into a comorbidity index provides superior guidance to clinicians evaluating patients as candidates for transplantation and treatments.
Sorror ML, et al. J Clin Oncol