Survival after HCT has improved significantly over time for adolescents and young adults (AYAs; age 15-40 years), according to a large-scale, multi-center study of 1,244 AYAs who underwent myeloablative allogeneic HCT for ALL at U.S. centers. Five-year adjusted overall survival during 1990-1995, 1996-2001, and 2002-2007 were 35%, 34%, and 45%, respectively (p<0.05). The same study, which analyzed HCT outcomes reported to the CIBMTR (Center for International Blood and Marrow Transplant Research), also revealed that from 1996-2001 to 2002-2007, transplant volume increased by 7% in children, 50% in AYAs, and 180% in older adults.
Wood WA, et al. BloodImproved HCT Survival over Time for Adolescents and Young Adults
Dec 2013