IPSS-R and Monosomal Karyotype Predict HCT Outcomes in MDS and AML

This multi-center study of 519 patients with myelodysplastic syndrome (MDS) or oligoblastic acute myeloid leukemia (<30% marrow blasts) demonstrated that both monosomal karyotype and revised International Prognostic Scoring System (IPSS-R) risk category are important factors predicting outcomes of allogeneic hematopoietic cell transplantation (HCT). Patients had a median age of 48 years (range 17-72) and were transplanted between 2000 and 2011. In a multivariate analysis, high-risk IPSS-R category and monosomal karyotype were independently associated with relapse and lower survival. The researchers concluded that “allogeneic HCT offers optimal eradication of myelodysplastic hematopoiesis when the procedure is performed before MDS patients progress to advanced disease stages.”

Della Porta MG, et al. Blood