This retrospective analysis comparing post-transplant infections in cord blood (n=65) and bone marrow/PBSC transplant recipients (n=369) found that although cord blood transplantation was associated with a higher risk of invasive aspergillosis and cytomegalovirus infections, infection-related mortality was comparable in the two types of transplants. Five-year survival was also comparable in the cord blood and marrow/PBSC groups, 38% vs. 43%, respectively (p=0.2). The researchers also compared rates of mortality attributable to invasive aspergillosis in two time periods—1997-2002 and 2003-2009—and found a significant decrease in mortality in patients with invasive aspergillosis over the two time periods: 59% vs. 25%, respectively (p=0.004).
Parody R, et al. Bone Marrow Transplant