This review discusses the practical clinical issues involved in the treatment of children with relapsed AML. The author notes that the probability of long-term survival from relapse is about 35%, which can only be achieved with very intensive chemotherapy and, usually, allogeneic HCT. Dr. Kaspers recommends that in the case of a suspected relapse, physicians should do a comprehensive diagnostic work-up, because significant changes in the biological features of the AML cells may have occurred between initial diagnosis and relapse.
Kaspers G. Brit J HaematolReview: How I Treat Relapsed AML in Children
Jun 2014