This review discusses the clinical evidence on FLT3-specific tyrosine kinase inhibitors (TKIs) being used as post-transplant maintenance in patients with FLT3-ITD acute myelogenous leukemia (AML) who are at high-risk for disease relapse. The authors report results from preliminary studies and case reports of FLT3 TKIs currently being evaluated in clinical studies, and note that early results indicate that post-transplant FLT3 TKI therapy is well-tolerated and may be effective in improving outcomes in patients.
Schiller GJ, et al. Biol Blood Marrow Transplant
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