Review: Post-Transplant High-Dose Cyclophosphamide to Prevent GVHD

This review article focuses on the mechanism of action of post-transplant cyclophosphamide, with a discussion of the clinical data on its efficacy in the prevention of GVHD. The authors note that cyclophosphamide can be especially effective against chronic GVHD in both matched related and unrelated donor settings, even when used as the sole GVHD prophylaxis. The authors also review emerging data on using cyclophosphamide in haploidentical HCT that suggest post-transplant cyclophosphamide together with standard prophylaxis reduces the incidence of GVHD to acceptable rates without the need for T cell depletion.

Al-Homsi AS, et al. Biol Blood Marrow Transplant

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