This review summarizes the mechanisms of action of sirolimus in preventing and treating graft-versus-host disease (GVHD). The authors discuss the immunosuppressive, antitumor, and antiviral properties of sirolimus, and analyze its potential advantages over other immunosuppressors. Topics include sirolimus in combination with tacrolimus in GVHD prophylaxis, sirolimus as primary therapy for acute GVHD, and sirolimus as a treatment for steroid-refractory acute and chronic GVHD.
Abouelnasr A, et al. Biol Blood Marrow Transplant