Updated Guidelines on HCT Graft Selection

This article presents updated guidelines on the selection of unrelated donors and cord blood units for hematopoietic cell transplantation (HCT) developed by the NMDP and the CIBMTR (Center for International Blood and Marrow Transplant Research). The guidelines are based on large-scale studies correlating graft characteristics — primarily degree of donor-patient HLA match — with HCT outcomes. Other topics addressed include optimal timing of transplant, donor search strategies, and strategies to select the best partially matched unrelated donor or cord blood unit.

Spellman SR, et al. Blood