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Recent Research

Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.

  • Review: Scientific advances in myelodysplastic syndromes

    March 2019

    Löwenberg B, Blood Journal – A series of review articles in the Blood Journal provides a comprehensive overview of the current landscape of MDS, highlighting advances in biological and clinical science.

    Read More

  • Adding genomic data to new prognostic model improves predictors of post-HCT outcomes in patients with MDS

    December 2018

    Nazha A, et al. ASH Annual Meeting 2018 - Researchers have developed a new personalized hematopoietic cell transplantation (HCT) outcomes prediction model for patients with myelodysplastic syndromes that incorporates both genomic and clinical data. The new genomic-clinical model can help physicians better identify patients who may or may not benefit from HCT. 

    Read More

  • Are the presence of post-HCT mutations in patients with MDS associated with higher risk of disease progression?

    October 2018

    Duncavage EJ, et al. N Engl J Med. – An exploratory study of 90 adults with myelodysplastic syndromes (MDS) evaluated the association of  mutations detected after allogeneic hematopoietic cell transplantation (HCT) with disease progression and survival. 

    Read More

  • Prognostic factors identified for MDS patients most likely to benefit from induction chemotherapy after HMA failure

    September 2018

    Researchers identified several prognostic factors for patients with myelodysplastic syndromes (MDS) who would most benefit from induction chemotherapies as a bridge to allogeneic hematopoietic cell transplantation (HCT) after hypomethylating agent (HMA) failure. (Ball B, et al. Blood Advances)

    Learn which prognostic factors led to higher response rates and overall survival

    Read More

  • Minimal Residual Disease Identifies Patients Who May Benefit from HCT in First Complete Remission

    June 2018
    Freeman SD, et al. J Clin Oncol – A large-scale, long-term study of adults with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) has shown that measurable or minimal residual disease (MRD) status can be used for risk stratification to determine which patients may benefit from hematopoietic cell transplantation (HCT).

    Read More

  • Haploidentical HCT is Safe and Effective for Older Patients with AML/MDS

    October 2017
    Ciurea SO, et al. Biol Blood Marrow Transplant – Haploidentical hematopoietic cell transplantation (HCT) is an appropriate therapy for older adults with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS), and can result in a 2-year progression-free survival (PFS) of 74% in selected patients.

    Read More

  • Vorinostat Can Lead to Lower Incidence of Acute GVHD

    September 2017
    Choi SW, et al. Blood – Adding vorinostat to a standard pre-transplant graft-versus-host disease (GVHD) prophylaxis can significantly lower the incidence of acute GVHD, according to results of a prospective, phase II study.

    Read More

  • Older Patients with MDS: Uncovering Barriers to Allogeneic HCT

    August 2017
    Getta BM, et al. Biol Blood Marrow Transplant – Only one-third of all patients with myelodysplastic syndromes (MDS) referred to an academic center undergo hematopoietic cell transplantation (HCT), according to a study of 362 patients with MDS treated at Memorial Sloan Kettering Cancer Center.

    Read More

  • Patients with MDS Responding to HMAs Have Better HCT Outcomes

    July 2017
    Festuccia M, et al. Biol Blood Marrow Transplant – Patients with myelodysplastic syndromes (MDS) who undergo hematopoietic cell transplantation (HCT) while still responding to hypomethylating agents (HMAs) have lower rates of post-HCT relapse, according to a study of 125 patients with MDS.

    Read More

  • Updated Recommendations for Selecting HCT Candidates in Patients with MDS

    March 2017
    de Witte T, et al. Blood –In this report from the European Society for Blood and Marrow Transplantation (EBMT), an international panel of experts present HCT treatment decision recommendations for patients with MDS.

    Read More

  • Updated Guidelines Identify Factors in Selecting HCT Candidates in Patients with MDS

    March 2017
    de Witte T, et al. Blood – In this report from the European Society for Blood and Marrow Transplantation (EBMT), an international panel of experts present treatment guidelines for patients with myelodysplastic syndromes (MDS).

    Read More

  • Improved HCT Outcomes for Fit Patients with MDS/AML After Standard Conditioning

    March 2017
    Scott BL, et al. J Clin Oncol – This randomized phase III trial of 272 adults with myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) found that patients with hematopoietic cell transplantation (HCT) comorbidity index scores ≤4 and with <5% marrow myeloblasts had better relapse-free survival (RFS) after HCT with myeloablative conditioning (MAC), than after reduced-intensity conditioning (RIC).

    Read More

  • Genetic Alterations Predict HCT Outcomes in Patients with MDS

    February 2017
    Lindsley RC, et al. N Engl J Med – TP53 mutations are the most important prognostic indicator in hematopoietic cell transplantation (HCT) for patients with myelodysplastic syndromes (MDS), independent of clinical factors, according to a multi-center study analyzing more than 1,500 transplants.

    Read More

  • Reclassified “Low Risk” Patients with MDS Achieve 58% 3-Year OS after HCT

    December 2016
    Robin M, et al. Bone Marrow Transplant – An analysis of 246 myelodysplastic syndrome (MDS) patients with low or intermediate-1 disease according to the International Prognostic Scoring System (IPSS) found that the majority of these patients (76%) actually had intermediate or higher-risk disease according to the revised IPSS.

    Read More

  • Somatic Mutations Can Improve Transplant Prognostics in MDS

    December 2016
    Rossi M, et al. ASH abstract oral presentation, December 2016 – In patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) evolving from MDS (MDS/AML), somatic mutation information can be combined with revised International Prognostic Scoring System (IPSS-R) risk categorizations to predict post-transplant relapse risk, according to research presented at ASH.

    Read More

  • Careful Selection of Older Patients with MDS Can Improve HCT Outcomes

    November 2016
    Heidenreich S, et al. Biol Blood Marrow Transplant – Researchers analyzing 313 patients over age 70 (median age 72 years) whose transplant outcomes were reported to the registry of the European Society for Blood and Marrow Transplantation (EBMT) found that careful selection of patients can significantly improve hematopoietic cell transplantation (HCT) outcomes.

    Read More

  • Somatic Mutations Improve Transplant Prognostics in MDS

    November 2016
    Della Porta MG, et al. J Clin Oncol – In a study of 401 patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) evolving from MDS (MDS/AML), researchers found that ASXL1, RUNX1, and TP53 mutations were independent predictors of higher rates of relapse and lower overall survival (p values <0.001 and p=0.017, respectively) after hematopoietic cell transplantation (HCT) in both patients with MDS and MDS/AML.

    Read More

  • Is Cord Blood the Best Alternative Graft Source for Patients with Minimal Residual Disease?

    October 2016
    Milano F, et al. N Engl J Med – A retrospective study of 582 patients with acute leukemia or myelodysplastic syndromes has shown that umbilical cord blood may be a superior graft choice for the approximately 70% of patients who lack an HLA-matched related donor, especially if they are minimal residual disease positive (MRD+).

    Read More

  • Early HCT Warranted in Therapy-Related MDS, AML

    June 2016
    Finke J, et al. Bone Marrow Transplant – In this long-term study of 79 patients with therapy-related myelodysplasia (t-MDS) or acute myeloid leukemia (t-AML), 10-year disease-free survival (DFS) and OS rates in this high-risk patient cohort were 35% and 38%, respectively.

    Read More

  • Scoring System Predicts Transplant Outcomes of Patients with MDS

    April 2016
    Shaffer BC, et al. J Clin Oncol – By studying 2,133 patients with myelodysplastic syndromes (MDS) undergoing allogeneic transplantation, researchers have developed an improved prognostic scoring system predictive of outcomes that integrates patient- and disease-specific factors beyond the IPSS-R scoring system.

    Read More

  • The Role of Pre-Transplant Clonal Burden in Myelodysplastic Syndromes

    March 2016
    Brierley CK, et al. Curr Opin Hematol – In this review, the authors review data on disease burden and transplant outcomes in myelodysplastic syndromes (MDS), and describe which MDS patients may benefit most from allogeneic hematopoietic cell transplantation (HCT).

    Read More

  • Patients Age 65 Years and Older with MDS Should Not Be Limited from Undergoing HCT

    December 2015
    Atallah E, et al. ASH abstract oral presentation, December 2015 – Patients over age 65 with myelodysplastic syndromes (MDS) should be considered transplant eligible, according to an oral presentation at the 2015 ASH Annual Meeting.

    Read More

  • Higher Relapse-Free Survival with Myeloablative HCT in Patients with AML and MDS

    December 2015
    Scott BL, et al. ASH abstract oral presentation, December 2015 – A phase III randomized trial presented at the ASH Annual Meeting has shown that although reduced-intensity regimens have lower treatment-related mortality (TRM), they also incur higher relapse rates.

    Read More

  • Azacitidine Feasible as a Bridge to HCT in Patients with Higher-Risk MDS or Low-Blast Count AML

    December 2015
    Voso MT, et al. ASH abstract oral presentation, December 2015 – A multi-center study of 93 patients with higher-risk MDS or low blast count AML demonstrated that induction with azacitidine (AZA) is a feasible “bridge to transplant,” with 52% of patients able to undergo HCT.

    Read More

  • New Scoring System Predictive of HCT Outcomes in Patients with MDS

    December 2015
    Shaffer BC, et al. ASH abstract oral presentation, December 2015 – Researchers analyzing transplant outcomes of 2,133 patients with myelodysplastic syndromes (MDS) have developed a prognostic scoring system that is more predictive of overall survival when compared to the IPSS and IPSS-R systems.

    Read More

  • BMT CTN Study to Compare HCT to Hypomethylating Agents to Treat MDS

    October 2014
    Saber W, et al. Biol Blood Marrow Transplant — This report outlines the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) trial to compare outcomes of reduced-intensity hematopoietic cell transplantation (HCT) in high-risk patients, 50-75 years of age, with myelodysplastic syndromes (MDS) with outcomes in patients with similar risk receiving novel nontransplant therapies such as hypomethylating agents.

    Read More

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Choose a Topic

  • All Topics
  • ASH 2017
  • AML
  • MDS
  • Lymphomas and CLL
  • Older Patient HCT
  • Sickle Cell Disease
  • Post-Transplant
  • GVHD
  • Patient Eligibility
  • CIBMTR Publications
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  • Pediatric HCT
  • ALL
  • CML
  • Multiple Myeloma
  • Neuroblastoma
  • Non-Malignant Disorders
  • HLA Matching
  • Preparative Regimens
  • BMT CTN Publications
  • Unrelated Donor HCT
  • ASH 2018
  • ASH 2020